N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide [CAS No. 171887-03-9]

Melting point >251°C (dec.)
Boiling point 554.8±60.0 °C(Predicted)
Density 1.742±0.06 g/cm3(Predicted)
Storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
Solubility DMSO, Methanol
Form Solid
Pka 10.90±0.70(Predicted)
Color Off-White to Pale Beige
Product ID: IM-002 Category:

Description

CAS No. 171887-03-9
Chemical Name: N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
Synonyms
N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide;2-Amino-4,6-dichloro-5-pyrimidinyl formamide;JACS-171887-03-9;2-Amino-4,6-dichloro-5-;N-(2-Amino-4,6-Dichloro-5-Pyri;2,5-Diamino-4,6-DichloroformamidoHcl;2-amino-4,6-dichloro-5-formamidopyrimidin;2-Amino-4,6-dichloro-5-formamidopyrimidine;2-Amino-4,6-dichloro-5-formanido pyrimidine;2-Amino-4,6-dichloro-5-formamidopyrimidine >
Molecular Formula: C5H4Cl2N4O
Molecular Weight: 207.02

Uses

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir – In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2”-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Uses

  • Prasugrel intermediate
  • Abacavir intermediate.
  • A purine derivative