Clopidogrel Bisulphate [CAS No. : 120202-66-6]

  • Molecular Formula :C 16 H 16 ClNO 2 S.H 2 SO 4
  • Molecular Weight : 419.90
  • CAS No : 120202-66-6
Product ID: AL-005 Category:
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Description

(S)-(+)-Clopidogrel is a prodrug that is metabolized by cytochrome P450 isoforms to produce an active metabolite, which is a selective, irreversible high-affinity antagonist of the platelet purinergic P2Y12 receptor. Potent antithrombotic antiplatelet agent. By inhibiting the Purinoceptor P2Y12 subtype it consequently inhibits ADP-induced platelet aggregation. (S)-(+)-Clopidogrel hydrogen sulfate is the active isomer. Compound can be used as analytical reference material.

Synonyms : Thieno [3,2-c] pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7- dihydro, methyl ester, (s)-sulfate (1:1)
Methyl (+)-(s)-α-(0-chlorophenyl)-6,7-dihydrothieno(3,2-c) pyridine-5(4H)-acetate, sulfate (1:1)

  • Handling Advice : Protect from light and moisture.
  • Use / Stability : Stable for at least 2 years after receipt when stored at +4°C.
  • Long Term Storage : +4°C
  • Short Term Storage : +4°C
  • Shipping : AMBIENT
Name Clopidogrel Bisulfate
Quality USP
IUPAC Name (+)-(S)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
Molecular Formula C16H18ClNO6S2
Molecular Weight 419.8943 gm/mol
CAS Number 120202-66-6
Physical Appearance A white to off-white powder
Solubility Freely soluble in water and in Methanol, practically insoluble in ether
Identification by IR Absorption A. IR absorption spectrum must be identical with Copidogrel Bisulfate working standard.

B. The retention time of the major peak in the chromatogram of the assay preparation corresponds to that of the standard preparation

C. It must give the reaction of sulfate
Relative Impurities
Impurity A
Impurity B
Impurity C
Any othe Impurity
Total Impurity		 Not more than 0.2%
Not more than 0.3%
Not more than 1.0%
Not more than 0.1%
Not more than 1.5%
Water (by K.F.) Not more than 0.5% w/w
Sulphated Ash Not more than 0.1% w/w
Assay (on dry basis) 97% to 101.5% as C16H15ClNO2S. H2SO4 on dried basis

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