Description

Nadifloxacin is a fluorinated fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, especially Propionibacterium acnes.  It also shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).  Nadifloxacin is capable of treating green nail syndrome caused by Pseudomonas aeruginosa.

Mechanism of Action: Nadifloxacin inhibits Topo II (DNA gyrase) in Gram-negative bacteria, and Topo IV in Gram-positive bacteria, which both function to relax positive supercoils prior to DNA replication, thus inhibiting bacterial multiplication.

Nadifloxacin can inhibit DNA gyrase activity involved in bacterial DNA synthesis and replication, thereby inhibiting bacterial proliferation. In vitro studies have shown that Nadifloxacin has a broad spectrum of antibacterial effect on aerobic Gram-positive bacteria, gram-negative bacteria and anaerobic bacteria are effective. In addition, studies have shown that naditoxin is also effective in inflammatory acne lesions, which may be related to its inhibitory effect on pro-inflammatory cytokines, such as interleukin (IL)-1α, IL-6 and IL-8, these factors play an important role in the pathogenesis of acne.

Application:

Spectrum: broad-spectrum activity against Gram-positive and Gram-negative bacteria.