Olaparib [CAS 763113-22-0]

CAS Number : 763113-22-0

Purity : >99%

Molecular Weight : 434.47

Molecular formula : C ₂₄ H ₂₃ FN ₄ O ₃

Category: Active Pharmaceutical Ingredients Tag: Olaparib

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Description

Description

Olaparib is a potent inhibitor of both PARP-1 and PARP-2, with IC50 = 5 nM and 1 nM, respectively. Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus Olaparib has an effect on activating BRCA2-dependent recombination pathways. Olaparib may act to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.

Exterior : Powder

Physical state : Solid

Solubility : Soluble in DMSO (33 mg/mL), ethanol (1.7 mg/mL), and water (<1 mg/mL at 25° C).

Store at -20° C

Melting point : 198-209° C

density : 1.4 g/cm ³ (Predicted)

Refractive Index : n ²⁰_D 1.70 (Predicted)

Alternative Name :

Olaparib also known as 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine; 4-[[3-[[4- (Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone; AZD 2281; KU 0059436; KU 59436; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4 -dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine

Application :

Olaparib is a potent inhibitor of both PARP-1 and PARP-2 and is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition